Ethics of sham surgery: Perspective of patients
Identifieur interne : 000E06 ( Main/Exploration ); précédent : 000E05; suivant : 000E07Ethics of sham surgery: Perspective of patients
Auteurs : Samuel A. Frank [États-Unis] ; Renee Wilson [États-Unis] ; Robert G. Holloway [États-Unis] ; Carol Zimmerman [États-Unis] ; Derick R. Peterson [États-Unis] ; Karl Kieburtz [États-Unis] ; Scott Y. H. Kim [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-01.
English descriptors
Abstract
Sham surgery is used as a control condition in neurosurgical clinical trials in Parkinson's disease (PD) but remains controversial. This study aimed to assess the perspective of patients with PD and the general public on the use of sham surgery controls. We surveyed consecutive patients from a university‐based neurology outpatient clinic and a community‐based general internal medicine practice. Background information was provided regarding PD and two possible methods of testing the efficacy of a novel gene transfer procedure, followed by questions that addressed participants' opinions related to the willingness to participate and permissibility of blinded and unblinded trial designs. Two hundred eighty‐eight (57.6%) patients returned surveys. Patients with PD expressed less willingness to participate in the proposed gene transfer surgery trials. Unblinded studies received greater support, but a majority would still allow the use of sham surgery. Those in favor of sham surgery were more educated and more likely to use societal perspective rationales. Patients with PD are more cautious about surgical research participation than patients with non‐PD. Their policy views were similar to others', with a majority supporting the use of sham controls. Future research needs to determine whether eliciting more considered judgments of laypersons would reveal different levels of support for sham surgery. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21775
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Ethics of sham surgery: Perspective of patients</title>
<author><name sortKey="Frank, Samuel A" sort="Frank, Samuel A" uniqKey="Frank S" first="Samuel A." last="Frank">Samuel A. Frank</name>
</author>
<author><name sortKey="Wilson, Renee" sort="Wilson, Renee" uniqKey="Wilson R" first="Renee" last="Wilson">Renee Wilson</name>
</author>
<author><name sortKey="Holloway, Robert G" sort="Holloway, Robert G" uniqKey="Holloway R" first="Robert G." last="Holloway">Robert G. Holloway</name>
</author>
<author><name sortKey="Zimmerman, Carol" sort="Zimmerman, Carol" uniqKey="Zimmerman C" first="Carol" last="Zimmerman">Carol Zimmerman</name>
</author>
<author><name sortKey="Peterson, Derick R" sort="Peterson, Derick R" uniqKey="Peterson D" first="Derick R." last="Peterson">Derick R. Peterson</name>
</author>
<author><name sortKey="Kieburtz, Karl" sort="Kieburtz, Karl" uniqKey="Kieburtz K" first="Karl" last="Kieburtz">Karl Kieburtz</name>
</author>
<author><name sortKey="Kim, Scott Y H" sort="Kim, Scott Y H" uniqKey="Kim S" first="Scott Y. H." last="Kim">Scott Y. H. Kim</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:D3248C0EF522C99D62389D99BA85264A555C3F71</idno>
<date when="2008" year="2008">2008</date>
<idno type="doi">10.1002/mds.21775</idno>
<idno type="url">https://api.istex.fr/document/D3248C0EF522C99D62389D99BA85264A555C3F71/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">000E46</idno>
<idno type="wicri:Area/Main/Curation">000C79</idno>
<idno type="wicri:Area/Main/Exploration">000E06</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Ethics of sham surgery: Perspective of patients</title>
<author><name sortKey="Frank, Samuel A" sort="Frank, Samuel A" uniqKey="Frank S" first="Samuel A." last="Frank">Samuel A. Frank</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Neurology, Boston University School of Medicine, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wilson, Renee" sort="Wilson, Renee" uniqKey="Wilson R" first="Renee" last="Wilson">Renee Wilson</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Rochester, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Holloway, Robert G" sort="Holloway, Robert G" uniqKey="Holloway R" first="Robert G." last="Holloway">Robert G. Holloway</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Rochester, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Zimmerman, Carol" sort="Zimmerman, Carol" uniqKey="Zimmerman C" first="Carol" last="Zimmerman">Carol Zimmerman</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Rochester, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Peterson, Derick R" sort="Peterson, Derick R" uniqKey="Peterson D" first="Derick R." last="Peterson">Derick R. Peterson</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Biostatistics and Computational Biology, University of Rochester, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kieburtz, Karl" sort="Kieburtz, Karl" uniqKey="Kieburtz K" first="Karl" last="Kieburtz">Karl Kieburtz</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Neurology, University of Rochester, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kim, Scott Y H" sort="Kim, Scott Y H" uniqKey="Kim S" first="Scott Y. H." last="Kim">Scott Y. H. Kim</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>Department of Psychiatry, the Bioethics Program, and the Center for Behavioral and Decision Sciences in Medicine, University of Michigan, Ann Arbor</wicri:cityArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2008-01">2008-01</date>
<biblScope unit="volume">23</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="63">63</biblScope>
<biblScope unit="page" to="68">68</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">D3248C0EF522C99D62389D99BA85264A555C3F71</idno>
<idno type="DOI">10.1002/mds.21775</idno>
<idno type="ArticleID">MDS21775</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term>
<term>gene therapy</term>
<term>placebo controlled trials</term>
<term>sham surgery</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Sham surgery is used as a control condition in neurosurgical clinical trials in Parkinson's disease (PD) but remains controversial. This study aimed to assess the perspective of patients with PD and the general public on the use of sham surgery controls. We surveyed consecutive patients from a university‐based neurology outpatient clinic and a community‐based general internal medicine practice. Background information was provided regarding PD and two possible methods of testing the efficacy of a novel gene transfer procedure, followed by questions that addressed participants' opinions related to the willingness to participate and permissibility of blinded and unblinded trial designs. Two hundred eighty‐eight (57.6%) patients returned surveys. Patients with PD expressed less willingness to participate in the proposed gene transfer surgery trials. Unblinded studies received greater support, but a majority would still allow the use of sham surgery. Those in favor of sham surgery were more educated and more likely to use societal perspective rationales. Patients with PD are more cautious about surgical research participation than patients with non‐PD. Their policy views were similar to others', with a majority supporting the use of sham controls. Future research needs to determine whether eliciting more considered judgments of laypersons would reveal different levels of support for sham surgery. © 2007 Movement Disorder Society</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Massachusetts</li>
<li>Michigan</li>
<li>État de New York</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Frank, Samuel A" sort="Frank, Samuel A" uniqKey="Frank S" first="Samuel A." last="Frank">Samuel A. Frank</name>
</region>
<name sortKey="Holloway, Robert G" sort="Holloway, Robert G" uniqKey="Holloway R" first="Robert G." last="Holloway">Robert G. Holloway</name>
<name sortKey="Kieburtz, Karl" sort="Kieburtz, Karl" uniqKey="Kieburtz K" first="Karl" last="Kieburtz">Karl Kieburtz</name>
<name sortKey="Kim, Scott Y H" sort="Kim, Scott Y H" uniqKey="Kim S" first="Scott Y. H." last="Kim">Scott Y. H. Kim</name>
<name sortKey="Peterson, Derick R" sort="Peterson, Derick R" uniqKey="Peterson D" first="Derick R." last="Peterson">Derick R. Peterson</name>
<name sortKey="Wilson, Renee" sort="Wilson, Renee" uniqKey="Wilson R" first="Renee" last="Wilson">Renee Wilson</name>
<name sortKey="Zimmerman, Carol" sort="Zimmerman, Carol" uniqKey="Zimmerman C" first="Carol" last="Zimmerman">Carol Zimmerman</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E06 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000E06 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:D3248C0EF522C99D62389D99BA85264A555C3F71 |texte= Ethics of sham surgery: Perspective of patients }}
This area was generated with Dilib version V0.6.23. |